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Mice were exposed to acute TBI by X-ray at 1, 3, and 5 Gy

Ferroptosis inhibitors could be administered in a specific time window after radiotherapy to protect normal brain tissues while allowing sufficient time for radiotherapy to exert its effects on tumor cells

Assessment of Brain Glutathione Peroxidase Activity The glutathione peroxidase (GSH-Px) activity was analyzed using colorimetric kits (Biodiagnostic Co, Cairo, Egypt) according to the manufacturers instructions