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1 Introduction Vitamin B12 (cobalamin) is a crucial water-soluble vitamin essential for various physiological processes that are vital to human health (Figure 1)

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5-Amino-1MQ acts as a competitive inhibitor with respect to the nicotinamide substrate (submicromolar IC50), increasing the intracellular nicotinamide available for NAD+ salvage via NAMPT - which is then studied for downstream effects on NAD+-dependent sirtuins and mitochondrial function

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