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4th et al

doi: 10.1016/j.freeradbiomed.2018.06.010 62 RobertsCKSindhuKK

Extracellular cGAMP is a cancer-cell-produced immunotransmitter involved in radiation-induced anticancer immunity

The critical knowledge gaps persist in defining optimal stress thresholds by adjusting dosing intervals and in modeling subpopulation dynamics (sensitive/tolerant ratios, proliferation kinetics) that govern tumor adaptation