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12(8): 2476 (2020) Liu Y, Tran DQ, Rhoads JM

Pharmacological activation of Nrf2: cardioprotective effects of statins and metformin against dyslipidemia-induced oxidative stress

AEROBIC GLUCOSE CATABOLISM ELECTRON TRANSPORT CHAIN SLO 1: Outline the process by which ATP is produced as a result of electron flow through the protein complexes of the Electron Transport Chain (ETC)

2 Mechanisms of hypoxia in the tumor microenvironment 2.1 Development of hypoxia in tumors Hypoxia is a common feature observed in approximately 90% of solid tumors and is widely recognized as a hallmark of cancer ( Figure 3 ) ( Figure 3 Hypoxia in tumors can be broadly categorized into two distinct forms: chronic hypoxia and acute (or cycling) hypoxia ( In contrast, acute hypoxia, also referred to as cycling or intermittent hypoxia, arises due to transient fluctuations in tumor blood flow ((no longer than 24 h))., leading to to oxygen levels below 1% that can be reversed with returned blood flow (24)