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Also, brain oxidative stress biomarkers, including brain malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD), brain-derived neurotrophic factor (BDNF) as well as heme oxygenase-1 (HO-1) were measured

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22 Notably, the rate constant (510 10 9 M 1 s 1 ) of this rapid bimolecular reaction between NO and superoxide is about three to four times faster than the dismutation of superoxide by the superoxide dismutase