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Abstract Background Non-communicable diseases (NCDs), including cardiovascular diseases, respiratory disorders, And age-related degenerative diseases, account for 74% of global mortality, imposing heavy burdens on healthcare systems and global sustainable development

Acknowledgements This work was supported by Fundao de Amparo Pesquisa do Estado de So Paulo to RCP (2016/14542-8), MAV (2015/04400-9), and AKT (2017/20106-9)