Cysteine deficiency and glutathione (GSH) synthesis inhibition contribute to ferroptosis (22, 41), while iron-chelating agents and lipophilic antioxidants can prevent ferroptosis (42)
On day 10 after tumor inoculation, 0.1 mg cystine hydrochloride in 100 L PBS or PBS alone was intratumoral administered to each mouse every other day and the tumor size was measured
Green tea and Cannabis can also cause a fixed drug eruption Hair and nails Attached is a very useful Overview of drug-induced hair and nail disorders written by Dr Shailee Patel and Dr Antonella Tosti, Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine Pigmentary (figures 16-19) Chronology - very variable, can be a long time after the medication was commenced Most commonly associated drugs - minocycline, amiodarone, anti-malarials, co-danthramer (can stain peri-anal and surrounding skin in patients with incontinence) Lichenoid (figures 20-23) Druginduced LP reactions represent approximately 10% of all LP cases Chronology - usually months (even years) after the first exposure to the medication Clinical features Can be clinically indistinguishable from normal LP although is frequently more severe, Wickham's striae are often absent, and nail and mucosal change less common In some cases the features are nonspecific, sometimes lesions may be scaly Mucosal lichenoid reactions can also be caused by drugs Photodistributed lichenoid lesions may occur with a number of drugs, including thiazide diuretics Most commonly associated medications - gold, antimalarials, thiazides, ACEI, NSAIDs, betablockers, quinine, penicillamine, lithium, sulfa drugs (including sulfonylurea hypoglycaemic agents, dapsone, sulfasalazine), and tramadol
Supplementary Materials Data Availability Statement All the relevant data are available from the corresponding authors upon reasonable request.
