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pneumoniae MGH 78578 (serotype K52) as a reference, the screened differentially abundant metabolites were mapped using the KEGG pathway database ( 3 Results 3.1 Antimicrobial susceptibility and clinical characteristics of the Klebsiella pneumoniae isolates The antimicrobial susceptibility results for each isolate are displayed in Table 1

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Activated PGC-1 synergizes with nuclear factor erythroid 2-like 1/2 (NRF1/2) to initiate the expression of nuclear-encoded mitochondrial genes such as cytochrome C oxidase subunit 4 (COX4) and mitochondrial transcription factor A (TFAM), ultimately increasing mitochondrial quantity and enhancing the membrane potential of newly formed mitochondria [89,90,91]