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J Extracell Vesicles 2021;10:e12175

10.1016/j.nut.2014.09.016 34

Understanding these metabolic reprogramming processessuch as PDK4-mediated pyruvate dehydrogenase inhibition and PKM2/PKM1 isoform switchingcould identify novel therapeutic targets by regulating key pathways like Anaphase-promoting complex/cyclosome and its coactivator Cdh1 (APC/C-Cdh1)-dependent PFKFB3 stabilization or pentose phosphate pathway activation

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