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Thus, these are in seeming contrast to some considerations about NO-sphincter relations (20-23), providing the dysfunction of the nitrergic pathway differently acting at the damaged tissue integrity (and obviously prevailed and different from those of NO-esophageal sphincter relaxation (20), obtained in intact dogs (21) or ferrets (22), or muscle strips (23))

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Direct intravenous administration bypasses these digestive hurdles entirely, leading to superior bioavailability

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