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Mechanical loading mediates human nucleus pulposus cell viability and extracellular matrix metabolism by activating of NF-B

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For a small, water-soluble copper peptide, absorption from that depot would be expected to be reasonably efficient, but the depot also gives local peptidases and the local copper environment a first opportunity to act on the molecule before it reaches the systemic circulation

Second, the emerging science on mitochondrial-derived peptides like MOTS-c suggests that our understanding of endurance biology is about to undergo a fundamental expansionone likely to yield new biomarkers, training-response models, and eventually therapeutic options