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F., Carroll, J., Ding, S., Fearnley, I

Oxidative stress induces cell damage by alteration of macromolecules, such as fatty acids in membrane, essential proteins, or DNA

Initial Metabolic Changes (Days 1-14): While cellular-level metabolic changes begin within hours of the first AOD-9604 administration, noticeable subjective effects typically emerge within the first one to two weeks

Besides, the loss of pericytes, as well as the decreased pericyte-to-EC ratio, resulted in a localized increase in permeability, and the decreased pericyte coverage implied the central nervous system (CNS) microvascular dysfunction [72]