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10.18433/J34G7P 86 LiY.TranV

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To achieve high accuracy in machine learning models, preprocessing steps such as transformation, normalisation, and feature selection of microbial data should be performed before providing it as input to the models [299]

After entering the nasopharynx, pathogens escape recognition and clearance from host immune cells by mimicking the host molecular structure or altering their own antigens, escaping the mucus and adhering to the upper respiratory epithelium ( The manner in which bacteria, viruses and fungi induce an immune response after invasion is somewhat different (Figure 1)