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Crucially, no signal of cardiac toxicity, cytokine release syndrome, or treatment-related ILD was observed, and no adverse events led to treatment discontinuation or death, supporting the clinical tolerability of JSKN016 within the studied dose range [101]

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The authors suggested that exosomes improved glucose and lipid metabolism by promoting autophagy

CPA digestion of albumin To initiate in vitro enzymatic cleavage by CPA, unfused albumin (WT or QMP) or albumin fused to GLP-1, FIX 9 , or ACE2 13 (15 M), in DPBS (pH 7.4) (Sigma-Aldrich), were incubated with 30 g/mL of human pancreatic CPA (Elastin Products Company, Inc.) for 5 h at 37 C on a shaker platform set to 450 RPM