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Nutrients 12 (6), 1603 (2020)

( A H ) LC-MS analysis of incorporation of [ 13 C]glucose-derived carbons into glutamate ( A ), -KG ( C ), GSH ( E ), and GSSG ( G ), as well as relative abundance of overall glutamate ( B ), -KG ( D ), GSH ( F ), and GSSG ( H ) among all detected metabolites involving TCA cycle and GSH synthesis after stable isotope labeling with [U- 13 C]glucose on day 7

The metabolic regulatory network integrates nutrient-sensing pathways encompassing glucose metabolism, lipid homeostasis, and amino acid flux, forming the pivotal pathological nexus linking DM to its pulmonary complications