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Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation

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This decline accelerates during caloric restriction, making the deficit state particularly catabolic

2.1.3.2 Preventing muscle loss and preserving insulin sensitivity Both Astragalus and yam have demonstrated protective effects against diabetes-related muscle wasting by modulating mitochondrial function through the Rab5a/mTOR signaling axis (35)