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In addition, several metastasis-associated processes promote ferroptosis, such as epithelial-mesenchymal transition (EMT), loss of cell-cell contact, the YAP1/TAZ activation, and the detachment of tumor cells from adjacent cells and the ECM 20

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Further research is needed to definitively link many of these CVD-associated ncRNAs to ferroptosis processes, and larger patient cohorts are required to validate their biomarker potential

tert -butylhydroquinone (tBHQ) will result in conformational changes in Keap1 cysteine residues, which interferes the interaction between Kelch domain and DLG motif where the ETGE motif still bound to Nrf2