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Treatment with memantine reduced irritability, stereotypic behavior, and hyperactivity in children with ASD [150] and improved social behaviors in children with ASD [151, 152]

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2019;186:132 Ethics declarations Conflict of interest The authors declare no competing interests

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Macrophage polarization toward the M2 phenotype under stimuli can facilitate this process by promoting stem cell differentiation and extracellular matrix remodeling [426]

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