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[10] [11] [12] [13] [14] Rich Van Konynenburg first postulated a depletion of glutathione was at the heart of many of the symptoms of CFS/ME, but quickly added information about methylation when he realized that the two were connected

Its effects on gene expression have been mapped and found to influence genes involved in neuronal development, maintenance, and synaptic function [9,16,17]

First, this was a single-center study with a relatively small sample size, despite being a prospective observational study

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