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Hydroquinone, for instance, has raised concerns about potential skin irritation and long-term use risks

Vitamin B12 deficiency may be treated with oral supplements or intramuscular injections depending on severity

10.1097/CCM.0000000000003555 216 KerinsM

However, in GDH 1 knock-out mice (only humans express GDH 2) most functions, except the already mentioned reduced glutamate oxidation in cultured astrocytes, are remarkably intact (Frigerio et al., Table 2 Oxygen consumption rates as indications of kinetics of glutamate-dehydrogenase and aspartateglutamate transferase activities in non-synaptic mitochondria from the rat