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However, other considerations may be important in vivo such as solvent accessibility of the individual Cys i.e., whether it is buried or accessible

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Manifestation of the quasi-species is dependent on the substrate matrix, implying that a dormant activity, such as steroid isomerization, will only become overt if the relevant substrate is present and the reaction provides selective advantage ( Statements Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication