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Conversely, we define Treg exhaustion more specifically as a state induced by chronic inflammation, characterized by persistent expression of inhibitory receptors (e.g., PD-1/TIGIT), metabolic insufficiency, epigenetic and lineage instability (such as FOXP3 destabilization), and a decline in suppressive capacity, particularly in the context of continuous antigenic and cytokine stimulation

This is because prostaglandins, which are blocked by COX inhibition, are important for proper blood vessel function within the kidneys (Ejaz 2004)

Functional medicine focuses on identifying and correcting the root cause of health issues rather than masking symptoms

Oksman et al., 2009)