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GSH and pyroptosis Pyroptosis is a form of lytic cell death characterized by gasdermin-mediated plasma membrane pore formation, leading to osmotic swelling, membrane rupture, and the release of mature pro-inflammatory cytokines, including interleukin 1 beta (IL1B, also known as IL-1) and interleukin 18 (IL18)

Further studies generated pharmacokinetic profiles of intranasal vascular endothelial growth factor in rats and intranasal allopregnanolone in mice, which measured the highest drug concentrations in the trigeminal nerve, optic nerve and olfactory bulb followed by the cerebrum and hippocampus [79, 80]

Drafting the manuscript for important intellectual content: K.S.H., K.P., W.W., H.S.-D., and S.J.C

J Hum Nutr Food Sci