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Given the potential influence of chemotherapy, all patients in the study had not previously received chemotherapy (2023)

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In another study, administration of caffeine (200 mg/kg body weight) negatively affected the male reproductive functions as demonstrated by the reduced testicular and epidydimal weight, distortion of the histo-architecture of the seminiferous tubule and loss of spermatogenic cells, sperm count, motility and viability with increase abnormal sperm 64,65

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