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TLR9 is functionally expressed in microglia and astrocytes, which serve as the brains primary immune effector and supporting glial cells, respectively [129]

Dizocilpine reduces cGMP levels in the cerebellum, but does not affect the cerebral cortex and hippocampus, while L-NAME and 7-NI reduce cGMP levels in the cerebral cortex and hippocampus (Yamada et al., 1996)