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662,663,664 Gapmer oligonucleotides complementary to the adenine-adenine-guanine repeat sequence within the Frataxin gene have shown a higher efficacy in activating Frataxin RNA and protein expression

Another is to block an enzyme in the skin called tyrosinase

Unlike SufB or SufC, the SufD domain does not contain Walker A, Walker B, or the ABC signature motif

314 A PEO mouse model with a C10orf2 defect has been established, 315 demonstrating that type IIB fibers of extraocular muscles are particularly vulnerable to mtDNA deletions, likely due to their relatively low mitochondrial content, which allows even a few mutant mtDNA to surpass the onset threshold