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In FM, melatonin has been shown to improve sleep quality, pain levels, and the pain threshold by enhancing the descending endogenous pain-modulating system [63]

EAE in non-chimeric animals displayed a difference in mortality, since this was not present in the chimeric EAE set-ups, so one cannot exclude Gsta4-dependent contributions from bone marrow-derived cells in non-chimeric EAE setting

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Sigma, NO761-100G) at doses of 100 mg/kg/day (Niacin 1) and 200 mg/kg/day (Niacin 2), corresponding to approximately 4 mg and 8 mg per mouse per day based on average body weights (2040 g)