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The iodine bonds to the tyrosine residues of thyroglobulin, and when most of the tyrosine residues on the thyroglobulin molecule have been iodinated, 2 iodinated tyrosine molecules then coalesce to form the precursors of the thyroid hormones T4 and T3 in about an 80/20 ratio

A high-throughput mutation screening of 16 patients with dilated or hypertrophic cardiomyopathy indicated that MGME1 variants are highly associated with the pathogenesis of heart disease (154)

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(1993) Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion