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HYGIENE A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS A61P9/00Drugs for disorders of the cardiovascular system AHUMAN NECESSITIES A61MEDICAL OR VETERINARY SCIENCE

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For example, PTEN mutations, which occur downstream of EGFR signaling, have been identified as a resistance factor in anti-EGFR therapy for GB, highlighting the complexity of these pathways and the challenges in developing effective targeted treatments ( Figure 1 further illustrates the intricate and overlapping signaling cascades within the RTK pathway, emphasizing the complexity involved in the context of the various targeted therapeutics discussed above