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DOI:10.1128/jb.176.12.3790-3799.1994 56

The Ser/Thr protein kinase ATM phosphorylates NCOA4 to enhance its interaction with ferritin, thereby increasing the ferritinophagy rate and the level of intracellular labile free iron, resulting in ferroptosis[62]

Obvious surrogate end points include blood pressure, lipid levels, glycemic control, intracellular antioxidants (red cell glutathione), microalbuminuria, and markers of inflammation