diethyl maleate glutathione depletion

diethyl maleate glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: Implications for systemic disease and immunosenescence REGULATION OF GLUTATHIONE SYNTHESIS -

Name: diethyl maleate glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: Implications for systemic disease and immunosenescence REGULATION OF GLUTATHIONE SYNTHESIS -
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REGULATION OF GLUTATHIONE SYNTHESIS PMC Diethyl maleate 97 141 05 9 Diethyl maleate inhibits MCA+TPA transformed cell growth via modulation of GSH, MAPK, and cancer pathways ScienceDirect Hepatic transcriptome and proteome responses against diethyl maleate induced glutathione depletion in the rat Archives of Toxicology Springer Nature Link

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Description

CL can be spread through physical contact of wounds and pus, through brushes and clippers, and through anything in the barnyard that pus may have touched, such as feed, equipment, fences and structures

When catalyzed by GST, the prodrug releases cytotoxic compounds

This represents a pharmaceutical design strategy of creating selectivity through structural modification, providing therapeutic benefits while minimizing unwanted effects