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++ Revise the Shared Savings Program regulations to broaden a limited exception to the program's voluntary alignment policy and allow a voluntarily aligned Shared Savings Program beneficiary to be claims-based assigned to an entity participating in a disease- or condition-specific CMS Innovation Center model when that model uses claims-based assignment that is based on primary care and/or other services and the Secretary has determined that a waiver is necessary solely for purposes of testing the model, in order for beneficiaries with certain diseases or conditions to benefit from the focused attention and care coordination related to the disease or condition that an entity participating in such a model can offer (section III.G.3.b of this final rule)

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PTMs such as phosphorylation and acetylation may not need to reach a very high stoichiometry to exert regulatory effects 51,52 , and we expect that in many cases, the extent of fold changes in cysteine redox states is likely to be as informative as the absolute percentage modified

But here's where I pause: all of this is in rodents