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Its two-step synthesis glutamate-cysteine ligase (GCL, rate-limiting, producing -glutamylcysteine at the cost of one ATP) followed by glutathione synthetase (adding glycine, consuming a second ATP) produces a tripeptide whose unusual -glutamyl linkage between glutamate's -carboxylate and cysteine's amine renders it resistant to cellular peptidases, enabling accumulation to 0.515 mM concentrations in most cell types

Glutathione soap is highly moisturising and can help retain moisture in the skin, making it ideal for those with dry or sensitive skin

(2019) Key role of streambed moisture and flash storms for microbial resistance and resilience to long-term drought Freshwater Biol., 64, 306322 24