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Of note, Trx2 is localized to the mitochondria and has been found to play an important role in limiting mitochondrial ROS production and regulating cardiac function 10,11

doi: 10.1016/j.nbd.2011.01.021

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For instance, AAV9-mediated delivery of the very longchain acylCoA dehydrogenase (VLCAD) gene was used to treat very long-chain acyl-CoA dehydrogenase deficiency, directly correcting the -oxidation defect and maintaining stable cardiac function for up to 6 months in mice ( 5.3.2 Stem cell therapy Stem cells possess the remarkable ability to self-renew and undergo multilineage differentiation, enabling them to develop into various cell types such as cardiomyocytes and vascular endothelial cells