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SPIOMET4HEALTH-efficacy, tolerability and safety of lifestyle intervention plus a fixed dose combination of spironolactone, pioglitazone and metformin (SPIOMET) for adolescent girls and young women with polycystic ovary syndrome: study protocol for a multicentre, randomised, double-blind, placebo-controlled, four-arm, parallel-group, phase II clinical trial

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Since C 0 depends on log P Ag + log P T pop , it varies as a function of time: when population affinity gets higher with GC rounds, the optimal concentration C 0 ( t ) decreases (Figure 5c)

Hou Y, Wang H, Wu J, Guo H, Chen X