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TPR domains typically mediate protein-protein interactions ( Ec CnoX, the TPR domain is composed of two similar subdomains with five -helices each that define a groove rich in charged residues ( FIGURE 1 Ec CnoX) whereas Cys63 is involved in the formation of mixed-disulfide complexes with substrate proteins, thereby protecting them from irreversible oxidation

"It occurs in people whose B12 deficiency is caused by pernicious anemia," explains vitamin B12 expert and researcher Ralph Green, MD, PhD, a Distinguished Professor at the UC Davis School of Medicine

S1 4 Representative images of O 2 generation in vitro

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