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While typically synthesized endogenously, Gln becomes conditionally essential during physiological stress, requiring dietary intake to meet increased demands (Brosnan 2003

10.3389/fnagi.2017.00068 59 PintoA

In most cells, glutathione is found at concentrations of 1-10 mM in the cytoplasm and at lower concentrations in subcellular organelles, including the nucleus, mitochondria, and endoplasmic reticulum