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Months prior, in 2014, Flint had switched its water supply from the Detroit water system to the Flint River

Direct GFP fluorescence of CXCR3 GFP/GFP mice together with immunolabeling of cell type specific markers for microglia (Iba1), astrocytes (GFAP), or oligodendroglia (Olig2) in the corpus callosum and cortex in CXCR3 deficient mice that had been exposed to cuprizone for 5 days (Scale bars: 20 m)

Flavonoids are known to possess protective effects in biological systems due to their capacity to transfer free radical electrons, chelate metal catalysts, activate antioxidant enzymes, reduce alpha-tocopherol radicals, and inhibit oxidases [43]

Despite species-specific differences, these studies collectively demonstrate that oxygen deprivation disrupts the normal testicular architecture required for sperm production