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Conversely, concomitant use of nicotine and rifabutin, a CYP2B6 inducer, will result in a modest increase in mediated metabolism of the substrate, potentially leading to a reduction in serum concentration and/or therapeutic effect (DrugBank Clinical API Plugins, 2024)

[37] [38] The evolution of NiSOD is currently predicted to have occurred around the time of the GOE when a decrease in aquatic bioavailability of Fe took place

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doi: 10.18632/aging.103435 207 YangM.FukuiH.EdaH.XuX.KitayamaY.HaraK.et al