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The authors inferred that smoking had a negative effect on radiological manifestations and delayed the time to sputum conversion, probably related to an attenuated IFN- response caused by direct tobacco smoke ( A prospective cohort study has been performed in India to determine the impact of smoking on TB treatment outcome and the prevalence of smoking habits among newly diagnosed individuals

However, previous reviews emphasize common mechanistic pathways such as inflammation and oxidative stress while emerging pathways particularly autophagy-related signaling are under explored

To our knowledge, this review provides the most integrated synthesis to date of luteolins chemical foundations, mechanistic actions, disease-specific effects, formulation advances, regulatory status, and translational implications

Strains and plasmids constructed for this study are available upon request