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AST, located in the cell membrane, scavenges free radicals, preserves membrane structure, enhances immune performance, and regulates gene expression, protecting cells from oxidative damage and maintaining tissue integrity 21,22

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However, it has been found that the pathological degradation of BBB hinders the proper delivery and action of therapeutic agents, due to a series of functional, structural, and biochemical changes at both the endothelial level and, consequently, in the perivascular and interstitial space [314]