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Trials that are in progress may clarify the best options for encouraging the maintenance of lifestyle change that is so critical to weight control

20, 55 As p53 abnormalities are associated with poor prognosis in MM, 2, 49 the ability of BSO+L-PAM to induce cell death by circumventing p53 loss-of-function may provide a viable therapeutic option for patients with del17p13 MM

Cerebral folate deficiency can cause progressive neurologic deterioration, such as psychomotor retardation with hypotonia and ataxia, dyskinesias, cognitive impairment, and seizures [31]