gsh glutathione s transferase transferases as mediators of signaling pathways involved in cell proliferation and cell death Glutathione-s-transferase enzymes role in detoxification

Small molecule-based cytotoxic agents have advantages of high oral availability, metabolic stability, and high membrane permeability, while having disadvantages of high toxicity, poor solubility, and lower selectivity than alternatives 71

Given that TET enzymes play a primary role as tumor suppressors, the ability to enhance 5hmC formation and DNA hypomethylation by vitamin C is of great interest in the maintenance of genomic stability, and cancer prevention and treatment (Figure 2B)

Importantly, NRF2-deficient mice exhibited aggravated psoriasis-like symptoms and reduced response to SFN treatment

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