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IPA, as a potent inducer of PGC-1, can significantly upregulate the expression and activity of PGC-1 by activating AMP-dependent protein kinase(AMPK) and silencing the deacetylase regulatory protein(SIRT1) (Majeed et al., 2021)

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Chronic and uncontrolled hyperglycemia leads to the formation of advanced glycated end products (AGEs), leading to the generation of reactive oxygen species (ROS) and stimulation of inflammatory cascade and resulting in DM complications [15-16]