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A consistent pattern emerges: evidence is mostly limited to animal studies human studies, where they exist, are small and short-term there are no high-quality trials reflecting real-world use, including combinations, higher doses or long-term administration

Further in vitro investigations using human vascular endothelial cells confirmed the increased expression of VEGFR2 mRNA and protein induced by BPC 157, though not VEGF-A (Hsieh et al

Thus, in states of hypoxia, erythropoietin production is upregulated, whereas with normal oxygen tension, production is downregulated

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