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N Engl J Med 368:15751584

In addition, intra-myocardial fibrosis, a hallmark of AF, was observed to increase in the atria of obese mice, as evidenced by aggravated collagen deposition, upregulated pro-fibrosis signaling (TGF-, -SMA, Smad3, collagen , and collagen ), and downregulated transcription of anti-fibrotic Smad7 (Figures 2KO)