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A separate experiment showed that low concentrations of His that alone did not demetallate CuHSA, substantially increased the rate of the HSA demetallation by EDTA: three and sixfold increases were observed in the presence of 50 M and 100 M of His, respectively (Fig

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and colleagues, once sexual stimulation takes place, relaxing factors from the endothelial cells in the penis are released with nitric oxide (NO), which is probably the principal neurotransmitter mediating penile erection