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Intracellular ROS measurement LNCaP cells were seeded at 6 10 4 cells/well in 24-well plates, adhered overnight and then incubated with conditioned media for 2.5 days before treatment with doxorubicin or taxol

Some of these statin-induced anticancer activities are dependent on the genome guardian, p53, even though p53-independent apoptotic pathways have also been reported ( The p53 exists in a mutated form in more than half of human cancers and can significantly up-regulate mevalonate metabolism and protein prenylation in cancer cells (Thurnher et al., 2012)