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The limitations of this work are that we included RCTs, non-RCTs, and observational studies, which may lower the overall quality of evidence of the included studies

Desnutrin is a 54 kDa protein that contains an N-terminal patatin-like domain that is found in many plant acyl hydrolases and is characterized by a conserved serine in the G X S X G motif, an alpha/beta-hydrolase fold, a conserved aspartate belonging to the D X (G/A) motif, and a glycine-rich region (130)

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Research indicates that AOD-9604 may act, at least in part, through beta-3 adrenergic receptor (3-AR) signaling a pathway tightly associated with fat oxidation in visceral and brown adipose tissue