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The canonical pathway relies on cystine uptake through system Xc for glutathione (GSH) synthesis, which serves as a cofactor for glutathione peroxidase 4 (GPX4)

[3] [2] [23] [15] A different version of the Moderna COVID-19 vaccine, sold under the brand name Mnexspike (mRNA-1283), was approved for medical use in the United States in May 2025, [48] [49] [50] and in the European Union in February 2026

However, it is important to acknowledge the limitations of this study, particularly the small sample size

[DOI] [PMC free article] [PubMed] [Google Scholar] 200.Knaub K., Sartorius T., Dharsono T., Wacker R., Wilhelm M., Schn C